Surface Modification of Biomaterials: A Quest for Blood Compatibility

Surface Modification of Biomaterials: A Quest for Blood Compatibility

Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility. A great deal of research efforts are attributed towards realising...

Plasma-surface modification of biomaterials

Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, las...

Studies on Surface Modification of Silicone Biomaterials

This paper presents our studies on surface modification of silicone elastomer by collagen grafting/coating and electron beam irradiation. Two types of collagen hydrolysates with different molecular weights were obtained and characterized, which were used in experiments. Both silicone elastomer crosslinking and collagen grafting on the surface of silicone elastomer were achieved by electron beam...

Blood compatibility of biomaterials made of recombinant spider silk

Surface modification of biomaterials for conjugation with human fetal osteoblasts.

Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, ope...